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2-Propanol For HPLC

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2-Propanol For HPLC
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Category
Product Code
60104010001730
HSN Code
29051220
CAS Number
67-63-0
Brand Name
Merck Millipore
Packing Size
1 LTR

What is 2-Propanol?

2-Propanol (Isopropyl Alcohol, CAS No. 67-63-0) is a clear, volatile solvent known for its high purity, making it ideal for HPLC applications. Its balanced chemical structure allows it to dissolve both polar and non-polar compounds, ensuring accurate separation and detection. In chromatography, it enhances method reproducibility and minimizes interference for precise, high-resolution analysis. Widely used across industries, 2-Propanol offers excellent solvency, purity, and performance in demanding analytical environments. 

Key Chemical Properties of 2-Propanol

2-Propanol is known for its exceptional chemical versatility and stable performance in high-sensitivity applications. Below are the core properties that support its extensive use in HPLC: 

  • Boiling Point: Approximately 82.6°C 
  • Melting Point: -89.5°C 
  • Solubility: Miscible with water, alcohol, ether, and chloroform 
  • Polarity: Moderately polar; facilitates interaction with a wide range of analytes 
  • UV Transparency: Low UV absorbance, ideal for HPLC detection systems 
  • Volatility: Evaporates quickly without leaving residues 
  • Purity Standard: Complies with stringent criteria required for HPLC-grade solvent applications. 

With ideal polarity and volatility, 2-Propanol is widely used for mobile phase prep, column cleaning, and sample dissolution. In reversed-phase HPLC, Acetonitrile HPLC is often paired with 2-Propanol to boost elution strength and minimize baseline noise. 

Molecular Formula and Composition

Understanding the chemical makeup of 2-Propanol helps illustrate its functional properties: 

  • Chemical Formula: C₃H₈O 
  • Molar Mass: 60.10 g/mol 
  • Structure: A secondary alcohol with a hydroxyl group (-OH) attached to the central carbon of a three-carbon chain 

This configuration classifies it as a secondary alcohol, enhancing its solvent power without excessive reactivity. Its molecular simplicity supports compatibility with other common solvents used in chromatographic systems. 

Physical Characteristics – Appearance & Handling

2-Propanol features a user-friendly physical profile that ensures safety and performance in laboratory and industrial settings: 

Attribute  Specification 
Appearance  Clear, colourless liquid 
Odor  Characteristic alcohol-like smell 
Density  Approximately 0.785 g/cm³ at 20°C 
Viscosity  Low viscosity; enables smooth flow in pumps and tubing 
Packaging Options  Sealed glass bottles, HDPE containers, metal cans, and IBC tanks 
Storage Guidelines  Store in a cool, dry place away from heat and ignition sources 

 

How is 2-Propanol for HPLC Manufactured?

2-Propanol is produced through two primary methods: 

  1. Hydration of Propene: The most common method involves the direct or indirect hydration of propylene derived from petroleum. This method delivers optimal yield while maintaining economic efficiency.
  2. Synthetic Routes for HPLC Grade: Post-production, the solvent undergoes rigorous purification via distillation, drying, and filtration to meet HPLC-grade specifications. This includes minimizing UV-active impurities, non-volatile residues, and moisture content. 

Each batch is tested against critical parameters such as UV absorbance, refractive index, and evaporation residue to ensure analytical suitability. 

Industrial Applications of 2-Propanol

Isopropyl Alcohol (2-Propanol) is widely used in HPLC and other scientific, industrial, and medical applications due to its non-reactive and adaptable nature. 

Analytical Chemistry: 

  • Commonly used in HPLC mobile phases 
  • Solvent for sample preparation and column flushing 
  • Compatible with both normal-phase and reverse-phase chromatography 
  • Paired with n-Hexane For HPLC in normal-phase chromatography to improve resolution of non-polar analytes. 

Pharmaceutical Sector: 

  • Used as a solvent for active pharmaceutical ingredient (API) analysis 
  • Used in excipients profiling and drug stability testing 

Laboratory Use: 

  • Applied in spectroscopy, titration, and general cleaning 
  • Functions as a drying agent due to its rapid evaporation rate. 

Electronics and Cleanroom Applications: 

  • Used in precision cleaning of electronic components 
  • Leaves no residue and ensures fast drying without moisture 

Healthcare and Sanitation: 

  • Key ingredient in disinfectants and antiseptic wipes (non-HPLC grades) 
  • Demonstrates broad-spectrum efficacy against various bacterial and viral pathogens. 

Conclusion

2-Propanol (Isopropyl Alcohol, CAS No. 67-63-0) is essential in HPLC for its volatility, solubility, and UV transparency, enabling accurate, high-sensitivity separations. Lab Chemicals supplies high-purity, research-grade 2-Propanol that meets stringent HPLC standards, ensuring safety, consistency, and precision across pharmaceutical, environmental, and industrial applications. 

Trust Lab Chemicals as your reliable source for propanol, isopropyl alcohol, and other premium solvents designed for advanced analytical performance. 

Molecular Formula and Composition

Understanding the chemical makeup of 2-Propanol helps illustrate its functional properties: 

  • Chemical Formula: C₃H₈O 
  • Molar Mass: 60.10 g/mol 
  • Structure: A secondary alcohol with a hydroxyl group (-OH) attached to the central carbon of a three-carbon chain 

This configuration classifies it as a secondary alcohol, enhancing its solvent power without excessive reactivity. Its molecular simplicity supports compatibility with other common solvents used in chromatographic systems. 

Physical Characteristics – Appearance & Handling

2-Propanol features a user-friendly physical profile that ensures safety and performance in laboratory and industrial settings: 

Attribute  Specification 
Appearance  Clear, colourless liquid 
Odor  Characteristic alcohol-like smell 
Density  Approximately 0.785 g/cm³ at 20°C 
Viscosity  Low viscosity; enables smooth flow in pumps and tubing 
Packaging Options  Sealed glass bottles, HDPE containers, metal cans, and IBC tanks 
Storage Guidelines  Store in a cool, dry place away from heat and ignition sources 

 

How is 2-Propanol for HPLC Manufactured?

2-Propanol is produced through two primary methods: 

  1. Hydration of Propene: The most common method involves the direct or indirect hydration of propylene derived from petroleum. This method delivers optimal yield while maintaining economic efficiency.
  2. Synthetic Routes for HPLC Grade: Post-production, the solvent undergoes rigorous purification via distillation, drying, and filtration to meet HPLC-grade specifications. This includes minimizing UV-active impurities, non-volatile residues, and moisture content. 

Each batch is tested against critical parameters such as UV absorbance, refractive index, and evaporation residue to ensure analytical suitability. 

Industrial Applications of 2-Propanol

Isopropyl Alcohol (2-Propanol) is widely used in HPLC and other scientific, industrial, and medical applications due to its non-reactive and adaptable nature. 

Analytical Chemistry: 

  • Commonly used in HPLC mobile phases 
  • Solvent for sample preparation and column flushing 
  • Compatible with both normal-phase and reverse-phase chromatography 
  • Paired with n-Hexane For HPLC in normal-phase chromatography to improve resolution of non-polar analytes. 

Pharmaceutical Sector: 

  • Used as a solvent for active pharmaceutical ingredient (API) analysis 
  • Used in excipients profiling and drug stability testing 

Laboratory Use: 

  • Applied in spectroscopy, titration, and general cleaning 
  • Functions as a drying agent due to its rapid evaporation rate. 

Electronics and Cleanroom Applications: 

  • Used in precision cleaning of electronic components 
  • Leaves no residue and ensures fast drying without moisture 

Healthcare and Sanitation: 

  • Key ingredient in disinfectants and antiseptic wipes (non-HPLC grades) 
  • Demonstrates broad-spectrum efficacy against various bacterial and viral pathogens. 

Conclusion

2-Propanol (Isopropyl Alcohol, CAS No. 67-63-0) is essential in HPLC for its volatility, solubility, and UV transparency, enabling accurate, high-sensitivity separations. Lab Chemicals supplies high-purity, research-grade 2-Propanol that meets stringent HPLC standards, ensuring safety, consistency, and precision across pharmaceutical, environmental, and industrial applications. 

Trust Lab Chemicals as your reliable source for propanol, isopropyl alcohol, and other premium solvents designed for advanced analytical performance. 

Welcome to Jignesh Agency Pvt Ltd, formerly known as Jignesh Agency, established in 1990 by our visionary Director, Jignesh U Pathak. With over three decades of experience, we have emerged as market leaders in India, specializing in providing a comprehensive range of laboratory chemicals, filtration products, bulk solvents, standards, impurities, chromatography consumables, plastic ware, and scientific instruments.

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