DIMETHYLSULFOXIDE for Residual analysis, Headspace analysis. GC Grade solvent.

Understanding the structure of dimethyl sulphoxide DMSO clarifies its high solvency power and compatibility with analytical instruments: 

• Chemical Formula: C₂H₆OS 

• Molecular Weight: 78.13 g/mol 

• Structure: A sulfur atom doubly bonded to oxygen and singly bonded to two methyl groups 

This unique molecular arrangement makes DMSO amphiphilic, allowing it to dissolve both aqueous and organic compounds—ideal for sample matrices that require comprehensive solvation. 

The GC-grade dimethyl sulphoxide is meticulously packaged to maintain purity and integrity during transport and use: 

Producing dimethyl sulphoxide GC-grade solvent involves a multi-stage process focused on purity and batch consistency: 

1. Synthesis Phase: DMSO is typically synthesized through the oxidation of dimethyl sulfide (DMS) using oxygen or nitric acid catalysts. 
2. Primary Distillation: Removes lower-boiling impurities and unreacted DMS 
3. Advanced Purification: Further purification removes trace metals, peroxides, and volatile organic impurities 
4. UV Absorbance Control: Filtration and polishing eliminate residues that could interfere with sensitive detectors 
5. Moisture Removal: Karl Fischer drying methods are employed to reduce water content below 0.05% 
6. Inert Packaging: Bottled under nitrogen or argon to prevent oxidative degradation 

Due to its versatile solvency and inert characteristics, dimethyl sulphoxide is widely adopted in both routine and specialized applications: 

1. Gas Chromatography (GC) 

• Used as a sample solvent for residual solvent analysis in pharmaceuticals 

• Compatible with headspace gas chromatography, especially for high boiling point analytes 

• Provides clean baselines and consistent reproducibility in volatile analysis 

• Often paired with nn dimethyl formamide and n-Hexane depending on analyte polarity and volatility requirements. 

2. Pharmaceutical Development 

• Solubilizing agent for active ingredients during formulation screening 

• Employed in bioavailability and stability studies 

• Used in in-vitro and in-vivo testing for controlled drug delivery studies 

3. Biotechnology & Life Sciences 

• Preservative and cryoprotectant in cell preservation protocols 

• Common in PCR and DNA sequencing buffer systems 

• Dissolves lipophilic bioactive compounds for pharmacological testing 

4. Industrial and Chemical Research 

• Acts as a reaction medium in polymer synthesis, photochemistry, and catalysis 

• Used as a carrier solvent in microelectronics and coating technologies 

• Supports sample dispersion in analytical surface science 

Dimethylsulfoxide (CAS No. 67-68-5) is a key solvent in analytical chemistry, ideal for trace analysis, headspace GC, and complex sample prep due to its broad solubility, inertness, and low UV absorbance. 

Lab Chemicals offers GC-grade DMSO with high purity, consistency, and full documentation—trusted by researchers worldwide. 

Whether you're conducting residual analysis or pharmaceutical development, rely on Lab Chemicals for high-quality dimethyl sulphoxide tailored to precision-driven applications. 

Is GC-grade Dimethyl Sulphoxide suitable for headspace analysis? 

Yes. GC-grade dimethyl sulphoxide DMSO has low volatility and minimal background noise, making it ideal for headspace analysis, even with high-boiling analytes. 

Can Dimethyl Sulphoxide dissolve both polar and non-polar analytes? 

Yes. Dimethyl sulphoxide is highly polar and amphiphilic, allowing it to dissolve a wide range of compounds from water-soluble molecules to hydrophobic organics. 

Why is the CAS No 67 68 5 important when purchasing DMSO? 

The identifier CAS No 67 68 5 ensures that laboratories use the correct grade and chemical structure of dimethyl sulphoxide, avoiding cross-contamination or incorrect solvent selection. 

Can DMSO be used for dissolving thermally stable pharmaceutical compounds? 

Absolutely. Dimethyl sulphoxide DMSO is often selected for challenging compounds that require strong polarity and thermal resistance during GC analysis. 

Does DMSO require inert-gas packaging? 

For GC-grade quality, dimethyl sulphoxide is often packaged under nitrogen or argon to prevent oxidation and maintain consistent analytical performance.