N,N-DIMETHYLFORMAMIDE for Residual analysis, Headspace analysis. GC Grade solvent.

Understanding the structure of NN-Dimethyl formamide explains its superior solvency and wide compatibility: 

• Chemical Formula: C₃H₇NO 

• Molar Mass: 73.09 g/mol 

• Structure: Composed of a formyl group linked to a nitrogen atom bearing two methyl substituents. 

As a tertiary amide, DMF exhibits a polar aprotic nature, enabling it to dissolve both polar and non-polar compounds—crucial for efficient sample extraction and preparation in trace-level analysis. 

Dimethylformamide stands out in analytical labs due to its manageable and efficient physical profile: 

GC-grade DMF is produced through a precise multi-step process to ensure ultra-high purity: 

• Synthesis: Formed by reacting dimethylamine with carbon monoxide under pressure with a catalyst. 

• Purification: Refined via fractional distillation under reduced pressure and polishing filtration. 

• Final Polishing: Removes moisture, non-volatile residues, and UV-absorbing impurities. 

• Testing & Certification: Verified for low water content, minimal residue, and high chromatographic purity. 

At Lab Chemicals, each batch of NN-Dimethylformamide meets strict GC-grade standards for dependable analytical performance. 

Owing to its purity, polarity, and solubility, DMF finds application across several industries, particularly in analytical and quality control environments: 

Residual Solvent Analysis: 

• Used in ICH Q3C-compliant residual solvent testing in pharmaceutical APIs and excipients 

• Supports Class 1, 2, and 3 solvent profiling in drug formulations 

• Enables precise LOD/LOQ analysis in trace-level contaminant detection 

Headspace Gas Chromatography: 

• Preferred solvent in headspace sample preparation due to its thermal stability 

• Similar to dimethyl sulphoxide, which also offers low-interference performance in GC headspace methods 

• Ensures no interfering peaks during GC runs 

• Compatible with USP <467> and EP 2.4.24 protocols 

Pharmaceutical & Chemical Synthesis: 

• Medium for reaction chemistry, especially amidation, esterification, and alkylation reactions 

• Solvent for peptide coupling and other bio-organic synthesis pathways 

Electronics & Polymer Industry: 

• Used in the manufacturing of semiconductor coatings and polyacrylonitrile fibres. 

• Suitable for membrane production and film casting. 

Research & Academia: 

• Preferred in analytical laboratories for precise trace-level quantification. 

• Employed in spectroscopy and other instrumental methods 

N,N-Dimethylformamide (C₃H₇NO, CAS No. 68-12-2) is a highly polar solvent ideal for residual analysis and headspace GC, offering clean baselines and reliable reproducibility. Lab Chemicals provides GC-grade nn dimethyl formamide crafted under strict quality control to meet top analytical and regulatory standards. Trusted in pharma, environmental testing, and R&D, our DMF ensures precise, compliant workflows. Choose Lab Chemicals—where analytical accuracy starts with high-purity solvents. 

Is NN-Dimethylformamide compatible with headspace GC? 

Yes. GC-grade nn dimethyl formamide has low vapor pressure and minimal background interference, making it suitable for headspace analysis of high-boiling analytes. 

Can Dimethylformamide dissolve complex sample matrices? 

Absolutely. Dimethylformamide is a powerful polar aprotic solvent capable of dissolving both polar and moderately non-polar compounds, ideal for multi-component matrices. 

How does CAS No. 68-12-2 help in identifying the correct solvent grade? 

CAS No. 68-12-2 confirms researchers are working with the correct chemical identity of dimethylformamide, preventing errors in pharmaceutical and analytical documentation. 

Why is NN-Dimethylformamide used frequently in pharmaceutical quality control? 

Its solvency power and compatibility with complex matrices make nn dimethyl formamide ideal for dissolving APIs, excipients, and impurities in QC workflows. 

Can DMF be used in combination with other solvents for GC methods? 

Yes. nn dimethyl formamide is often mixed with polar solvents like methanol or acetonitrile to adjust elution strength and improve solubility of sample components.